Postop Pain Differs by Vitamin D Status

To investigate the relationship between preoperative vitamin D status and postoperative pain levels in breast cancer surgery patients.

17% of vitamin D-deficient patients reported moderate to severe pain at 12 hours post-surgery compared to 2% in the vitamin D-sufficient group.
At 6 hours post-surgery, moderate to severe pain was reported by 33% of vitamin D-deficient patients versus 20% of those with sufficient vitamin D.
Vitamin D deficiency was associated with more than three times the odds of experiencing moderate to severe postoperative pain during the first 24 hours after surgery.

The study was conducted at a single center with all participants being Egyptian, which may limit generalizability.
Short follow-up period and lack of assessment of inflammatory markers, anxiety, depression, cancer stage, neoadjuvant therapy, or sleep disturbance.