Objective:
To propose a method that combines hardware adaptive optics optical coherence tomography (AO-OCT) with computational aberration correction (CAC) to extend depth of focus in retinal imaging.
Key Findings:
- CAC enables cellular-level resolution across the full retinal thickness from a single focus setting.
- The technique allows simultaneous visualization of multiple retinal layers in a single volumetric dataset.
- In healthy eyes, CAC provides clear visualization of photoreceptors even at 1.5° from the fovea.
- In a patient with multiple sclerosis, CAC-enhanced imaging revealed significant ganglion cell loss and improved cone photoreceptor delineation.
Interpretation:
CAC enhances image sharpness across retinal layers without the need for multiple focus acquisitions.
Limitations:
- Good acquisition quality remains essential for effective CAC.
- Computational demands are a consideration, although defocus-only correction can be performed quickly.
Conclusion:
The hybrid approach of combining hardware AO-OCT with CAC may enhance the diagnosis and monitoring of retinal diseases.
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