Opioid overdose and cardiovascular disease-related mortality: a retrospective analysis using real-world data from the USA, 1999–2023 - Summary - MDSpire

Opioid overdose and cardiovascular disease-related mortality: a retrospective analysis using real-world data from the USA, 1999–2023

  • By

  • Mohamed Fawzi Hemida

  • Alyaa Ahmed Ibrahim

  • Maryam Saghir

  • Ahmed Elshahat

  • Mohammad Rayyan Faisal

  • Moaz Elsayed Abouelmagd

  • Zeyad Kholeif

  • Krish Patel

  • Noha Hammad

  • Pakeezah Tabasum

  • Eshal Saghir

  • Mohammed Hammad Jaber Amin

  • Ahmed Elmorsy Mohamed

  • Khaled Ali

  • Basel Abdelazeem

  • Mustafa Al-jarshawi

  • May 13, 2026

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Objective:

To characterize long-term trends and disparities in mortality involving both opioid overdose and cardiovascular disease (CVD) from 1999 to 2023.

Key Findings:
  • 112,430 deaths involving both opioid overdose and CVD were identified.
  • AAMR increased from 0.36 in 1999 to 4.08 in 2023 (AAPC: 10.96; p < 0.001).
  • Men had higher mortality rates than women (AAMRs: 2.51 vs. 0.99).
  • Non-Hispanic Black individuals showed the steepest increase in AAMR (from 0.33 to 6.48).
  • Non-metropolitan areas had higher AAMRs compared to metropolitan areas (1.56 vs. 1.47).
Interpretation:

The surge in opioid overdose and CVD-related mortality highlights significant disparities affecting specific demographics, particularly men and non-Hispanic Black individuals, necessitating targeted public health interventions.

Limitations:
  • Data limited to adults aged 15 and older, potentially missing trends in younger populations, which may affect the overall understanding of the epidemic.
  • Urban-rural classification data only available for 1999-2020, limiting the analysis of trends in more recent years.
Conclusion:

Opioid overdose and CVD-related mortality have surged, disproportionately affecting certain demographics and regions, indicating a need for integrated health strategies.

Original Source(s)

Opioid overdose and cardiovascular disease-related mortality: a retrospective analysis using real-world data from the USA, 1999–2023

  • by Mohamed Fawzi Hemida, Alyaa Ahmed Ibrahim, Maryam Saghir, Ahmed Elshahat, Mohammad Rayyan Faisal, Moaz Elsayed Abouelmagd, Zeyad Kholeif, Krish Patel, Noha Hammad, Pakeezah Tabasum, Eshal Saghir, Mohammed Hammad Jaber Amin, Ahmed Elmorsy Mohamed, Khaled Ali, Basel Abdelazeem, Mustafa Al-jarshawi

  • May 13, 2026

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