To identify latent profiles of psychiatric comorbidity among adolescents with substance use disorders (SUD) or alcohol use disorders (AUD) in Nigeria, highlighting the significance of these profiles in the context of limited mental health resources, and examine associations with suicidality and functional impairment.
Key Findings:
Identification of distinct latent profiles of psychiatric comorbidity among substance-affected adolescents, with implications for targeted interventions.
Significant associations between class membership and levels of suicidality and cumulative adversity.
Variability in functional impairment across identified classes.
Interpretation:
The findings suggest that psychiatric multimorbidity among substance-affected adolescents in Nigeria is complex and varies significantly, underscoring the need for tailored mental health interventions.
Limitations:
Cross-sectional design limits causal inferences.
Sample may not represent out-of-school adolescents, potentially underestimating the burden of psychiatric comorbidity.
Potential biases in self-reported data may affect the accuracy of findings.
Conclusion:
Understanding the profiles of psychiatric comorbidity can inform targeted mental health strategies for substance-affected adolescents in resource-limited settings like Nigeria, emphasizing the urgent need for intervention.
Genetically predicted urinary metabolite levels were associated with schizophrenia, bipolar disorder, attention-deficit/hyperactivity disorder, and anorexia nervosa in a Mendelian randomization analysis.
