To evaluate circulating macro- and trace elements alongside oxidative stress markers in women with endometrial cancer (EC) and ovarian cancer (OC), emphasizing the significance of these evaluations in understanding disease mechanisms.
Key Findings:
In EC, higher tumor grade correlated with lower levels of Ca, Mg, and Fe, and higher levels of Mn, Cu, Pb, and Cd, with decreasing trends also observed for K and Zn.
In OC, similar patterns were observed, particularly in patients requiring surgery followed by chemotherapy.
Redox profiling showed decreased TAS and increased TOS and OSI across tumor grades and clinical subgroups.
Interpretation:
Distinct yet overlapping alterations in elemental composition and redox balance are associated with EC and OC, reflecting complex interactions between disease, host response, and environmental factors, with potential implications for clinical practice.
Limitations:
Causality cannot be established due to the observational nature of the study.
Demographic and metabolic factors showed weak associations with elemental and redox changes.
Sample size limitations may affect the generalizability of the findings.
Conclusion:
Combined multi-element and redox profiling may provide insights into the systemic biochemical characteristics of gynecologic malignancies, necessitating further studies for clinical relevance and potential future research directions.
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