From anaphylaxis to eosinophilic esophagitis during omalizumab treatment in a boy with severe asthma and food allergy: a case report - Summary - MDSpire

From anaphylaxis to eosinophilic esophagitis during omalizumab treatment in a boy with severe asthma and food allergy: a case report

  • By

  • Urszula Jedynak-Wąsowicz

  • Liliana Klim

  • Ewa Cichocka-Jarosz

  • May 29, 2026

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Objective:

To report a case of eosinophilic esophagitis (EoE) in a child with severe IgE-mediated cow’s milk allergy and asthma during ongoing omalizumab treatment, highlighting the complexities involved.

Key Findings:
  • The patient had a history of IgE-mediated cow’s milk allergy and severe asthma.
  • While on omalizumab, the patient tolerated less processed dairy products for several months.
  • He subsequently developed recurrent vomiting and anaphylaxis after consuming ice cream.
  • Upper endoscopy confirmed esophageal inflammation and histological diagnosis of EoE.
  • Treatment with proton pump inhibitors and topical budesonide led to clinical improvement.
Interpretation:

The case highlights the need to consider EoE in highly atopic patients who develop persistent gastrointestinal symptoms during dietary liberalization, emphasizing the importance of monitoring.

Limitations:
  • Causal inferences regarding the relationship between omalizumab treatment and EoE cannot be made.
  • The case is based on a single patient experience, necessitating further research.
Conclusion:

This case illustrates the complexity of managing atopic conditions and the potential emergence of EoE during dietary changes in patients with severe allergies, underscoring the need for a multidisciplinary approach.

Original Source(s)

From anaphylaxis to eosinophilic esophagitis during omalizumab treatment in a boy with severe asthma and food allergy: a case report

  • by Urszula Jedynak-Wąsowicz, Liliana Klim, Ewa Cichocka-Jarosz

  • May 29, 2026

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