Cognition Associated With Future Depression Risk - Summary - MDSpire

Cognition Associated With Future Depression Risk

  • By

  • Kathryn Wighton

  • June 1, 2026

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Objective:

To investigate the relationship between cognitive performance and future depression risk in individuals with remitted depression compared to matched controls.

Key Findings:
  • Participants with remitted depression had higher odds of experiencing future depression compared to controls.
  • 33% of participants with remitted depression experienced depressive relapse compared to 13% of controls who developed first-episode depression.
  • Lower baseline cognitive performance in controls was associated with higher future depression risk.
  • Among participants with remitted depression, higher cognitive performance was linked to greater future depression risk.
Interpretation:

Limitations:
  • Estimated timing of depressive episodes during follow-up may not be accurate.
  • Incomplete cognitive data could affect results.
  • Limited power for resting-state functional MRI analyses.
  • Population representativeness is limited, with over 95% of participants being White.
Conclusion:

Original Source(s)

Cognition Associated With Future Depression Risk

  • by Kathryn Wighton

  • June 1, 2026

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