Editorial: The role of circular RNAs and MicroRNAs in non-small cell lung cancer: from mechanisms to therapeutic potential
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By
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Alexandru Tirpe
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Paola Campomenosi
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Ioana Berindan-Neagoe
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May 27, 2026
Objective:
To advance the understanding of the roles of microRNAs (miRNAs) and circular RNAs (circRNAs) in non-small cell lung cancer (NSCLC).
Key Findings:
- CircUBE2G1 promotes lymphangiogenesis and metastasis in LUAD.
- Circ_0001859 is involved in NSCLC growth and metastasis through its regulatory axis.
- High miR-20a-5p predicts favorable survival, while miR-17-5p is linked to poor prognosis in specific patient contexts.
- miR-155 modulates key biological processes in NSCLC and has potential as a diagnostic biomarker.
- The review integrates coding mutations with non-coding RNA regulation, providing insights into therapeutic interventions.
Interpretation:
Limitations:
Conclusion:
