Early high-resolution immune profiles are associated with survival, relapse and graft-versus-host-disease after allogeneic hematopoietic cell transplantation - Summary - MDSpire

Early high-resolution immune profiles are associated with survival, relapse and graft-versus-host-disease after allogeneic hematopoietic cell transplantation

  • By

  • Patrick Terrence Brooks

  • Lia Minculescu

  • Hans Jakob Hartling

  • Rebecca Svanberg Teglgaard

  • Jose Antonio Salado-Jimena

  • Lone Smidstrup Friis

  • Brian Kornblit

  • Ida Schjødt

  • Søren Lykke Petersen

  • Niels Smedegaard Andersen

  • Jens Lundgren

  • Susanne Dam Nielsen

  • Lars Klingen Gjærde

  • Hanne Vibeke Marquart

  • Henrik Sengeløv

  • Sisse Rye Ostrowski

  • May 30, 2026

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Objective:

To evaluate the associations between immune cell composition and function at day +28 post-allogeneic hematopoietic cell transplantation (allo-HCT) and clinical outcomes such as survival, relapse, and graft-versus-host disease (GvHD).

Key Findings:
  • Increased immune cell counts in both innate and adaptive compartments were associated with improved survival.
  • Elevated myeloid and innate lymphoid subsets correlated with lower relapse incidence.
  • Increased PD-1 expression on CD4 T cells and HLA-DR on CD8 T cells were linked to poorer overall survival.
Interpretation:

Remove unsupported conclusions and focus on summarizing findings.

Limitations:
  • The study is limited to a single cohort and may not be generalizable to all allo-HCT patients.
  • Further research is needed to validate the findings and explore the clinical applicability of the identified immune profiles.
Conclusion:

Revise to eliminate implications and focus on findings.

Original Source(s)

Early high-resolution immune profiles are associated with survival, relapse and graft-versus-host-disease after allogeneic hematopoietic cell transplantation

  • by Patrick Terrence Brooks, Lia Minculescu, Hans Jakob Hartling, Rebecca Svanberg Teglgaard, Jose Antonio Salado-Jimena, Lone Smidstrup Friis, Brian Kornblit, Ida Schjødt, Søren Lykke Petersen, Niels Smedegaard Andersen, Jens Lundgren, Susanne Dam Nielsen, Lars Klingen Gjærde, Hanne Vibeke Marquart, Henrik Sengeløv, Sisse Rye Ostrowski

  • May 30, 2026

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