To assess the prophylactic efficacy of oliceridine against fentanyl-induced cough (FIC) and characterize its peri-induction safety profile, highlighting the clinical significance of FIC.
Key Findings:
No patients in the oliceridine group experienced FIC, compared to 58.33% in the saline group (p < 0.001).
Cough severity in the saline group was classified as mild (17.86%), moderate (20.24%), and severe (20.24%), with statistical significance noted.
Interpretation:
Pretreatment with 2 mg oliceridine effectively reduces the incidence of FIC without significant additional risks, supporting its use in anesthetic induction and suggesting implications for clinical practice.
Limitations:
Single-center study may limit generalizability and introduce potential biases.
Small sample size may affect the robustness of findings.
Conclusion:
Oliceridine is a safe and effective option to reduce FIC during anesthesia induction, warranting further studies to confirm these findings.
