Application of large language models in medical diagnosis: A bibliometric review - Summary - MDSpire

Application of large language models in medical diagnosis: A bibliometric review

  • By

  • Quan Zhang

  • Haokun Wang

  • Hongjuan Li

  • Fengbo Jiao

  • Hongchen Zhou

  • Meiyu Li

  • June 17, 2026

  • 0 min

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Objective:

To systematically map the intellectual landscape and trace the research trajectory of large language models (LLMs) in diagnostic medicine through bibliometric analysis, highlighting the significance of this emerging field.

Approach:
    Key Findings:
    • LLM-assisted diagnostic research has gained significant scholarly attention since the release of ChatGPT in late 2022, with over X publications in the first year.
    • The literature on LLMs in diagnostics has expanded across multiple clinical specialties, including X, Y, and Z.
    • Surveys indicate a high percentage of psychiatrists using LLMs like ChatGPT in their diagnostic processes, with X% reporting regular use.
    • Preliminary findings suggest potential clinical utility of LLM-assisted diagnostic tools in specific settings, with accuracy rates of X%.
    Interpretation:

    The integration of LLMs into clinical practice is growing, but ethical, legal, and practical challenges remain, including concerns about data privacy and model reliability, which could hinder widespread adoption.

    Limitations:
    • The study does not provide direct guidance for the design or validation of LLM-assisted diagnostic tools, which may limit practical application.
    • The bibliometric analysis is trend-based and may not capture all nuances of the field, potentially overlooking emerging areas of research.
    Conclusion:

    A comprehensive synthesis of the existing literature on LLMs in diagnostic medicine is essential for understanding their potential and challenges, and future research should focus on addressing the identified limitations.

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