To investigate frequency-specific alterations in interhemispheric functional connectivity in patients with schizophrenia using voxel-mirrored homotopic connectivity (VMHC) analysis.
Key Findings:
Patients with schizophrenia showed significantly reduced VMHC in primary sensory networks, including visual and sensorimotor regions.
Higher VMHC was observed at slow-5 compared to slow-4 in visual gyrus and subcortical regions.
Significant group-by-frequency interactions were found in the middle occipital gyrus and postcentral gyrus, with reduced slow-4 VMHC in schizophrenia patients.
Interpretation:
The findings indicate frequency-dependent reductions in interhemispheric connectivity in schizophrenia, particularly affecting sensory systems.
Limitations:
The study's cross-sectional design limits the ability to draw conclusions about the clinical significance of the findings over time.
The sample size may restrict the generalizability of the results.
Conclusion:
Frequency-resolved VMHC analyses provide insights into network dysfunction in schizophrenia, warranting further longitudinal studies.
