Diagnostic challenges in COVID 19 and dengue co-infection: a case series report from tertiary care centers of Saudi Arabia - Summary - MDSpire

Diagnostic challenges in COVID 19 and dengue co-infection: a case series report from tertiary care centers of Saudi Arabia

  • By

  • Ashwaq M. Al-Nazawi

  • Maseer Khan

  • Anjum Qadir

  • Rana Alghamdi

  • Alzahrani Ali Ahmed

  • Wafa Ali Hetany

  • Mohammad H. Alharbi

  • June 10, 2026

  • 0 min

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Objective:

To analyze the clinical presentation of patients suspected of dengue and/or COVID-19, emphasizing the critical need for timely diagnosis and management.

Key Findings:
  • Mean age of patients was 39 ± 11.8 years, with 86% male and 14% female participants.
  • Common symptoms included fever, headache, myalgia, and rash, with a cutaneous rash observed in 36% of patients.
  • Misdiagnoses occurred due to atypical presentations, including a case initially diagnosed as dengue but later confirmed as COVID-19, highlighting the need for careful evaluation.
  • Co-infection cases exhibited more severe symptoms and prolonged recovery compared to mono-infected cases.
  • Most patients recovered after supportive management, but co-infected patients had extended hospitalization.
Interpretation:

The case series highlights the diagnostic complexity posed by the clinical similarity between dengue and COVID-19, particularly in endemic settings, and its implications for healthcare systems.

Limitations:
  • Retrospective design may limit the comprehensiveness of data and introduce potential biases.
  • Small sample size may not be representative of the broader population.
Conclusion:

Accurate and early differentiation through combined clinical and laboratory approaches is crucial to avoid misdiagnosis, ensure appropriate treatment, and reduce morbidity, especially in endemic regions.

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