Diagnosis-to-Ablation Time and Atrial Arrhythmia Recurrence After Ablation - Summary - MDSpire
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Impact of Time from Diagnosis to Ablation on Recurrence of Atrial Arrhythmias Post-Ablation

  • By

  • Matthew J. Singleton

  • Christopher Thorne

  • Chang Dai

  • Daniela Hincapie

  • Daniel Campos-Villarreal

  • Susan M. Bezenek

  • Linda Justice

  • Allyson Varley

  • Obadah Aloum

  • Joshua Silverstein

  • Chinmaya Mareddy

  • Paul C. Zei

  • Bruce A. Koplan

  • Saumil Oza

  • Anil Rajendra

  • Matthew Sackett

  • Edmond Obeng Gmiyah

  • Matthew Sellers

  • Ghanshyam Shantha

  • Amit Thosani

  • Jefferson H. Lee

  • Jose Osorio

  • REAL-AF Investigators

  • Wai Tam

  • Srinivas Rajsheker

  • Alexandru Costea

  • Rajan Shah

  • Christopher Woods

  • Kavisha Patel

  • Rajat Goyal

  • Richard Hongo

  • Steven Kang

  • Amir Schricker

  • Smit Vasaiwala

  • Mohit Rastogi

  • Devi Nair

  • Jose Osorio Filho

  • Gustavo Morales

  • Francis Benn

  • Macy Smith

  • Karl Ilg

  • Joshua Greenberg

  • Waddah Maskoun

  • Arfaat Khan

  • Mark Lahiri

  • Mohamad Raad

  • Matthew Ebinger

  • Jeremiah Wasserlauf

  • Alex Ro

  • Jose Nazari

  • Mark Metzl

  • Sunil Vasireddi

  • Jennifer Wright

  • Christopher Purtell

  • Matthew Kalscheur

  • Ryan Kipp

  • Daniel Modaff

  • Blake Fleeman

  • Majid Mughal

  • Mohammad Kanjwal

  • Michael Rehorn

  • Alap Shah

  • Tharian Cherian

  • Emerson Liu

  • Charles Miller

  • William Belden

  • Mati Friehling

  • George C. Shaw

  • Subha Varahan

  • Charles Te

  • Sarah Levin

  • Ethan Hoch

  • David Steckman

  • Daniel Buerkel

  • Daniel Pelchovitz

  • Andrew Noll

  • Scott Ferreira

  • John Garner

  • Paul Zei

  • Bruce Koplan

  • Thomas Tadros

  • Jorge Romero

  • Nathaniel Steiger

  • Dinesh Sharma

  • Anthony Magnano

  • Benjamin D'Souza

  • Sandeep Goyal

  • Michael Hoosien

  • Kavita Krishnasamy

  • Ashish Bhimani

  • Javier Sanchez

  • Rajeev Joshi

  • Kamala Tamirisa

  • Sunil Reddy

  • Jodie Hurwitz

  • Brett Gidney

  • Edwin Zishiri

  • Bipin Ravindran

  • Shrinivas Hebsur

  • Mohammad-Ali Jazayeri

  • Xu Gao

  • Andrew Hughey

  • Asim Ahmed

  • Jonathan Dukes

  • Emmanuel Ekanem

  • Evan Martow

  • Kenneth Quadros

  • Kyle Murray

  • Antonio Moretta

  • Matthew Singleton

  • Edmond Obeng-Gyimah

  • Jefferson Lee

  • Jose Silva

  • Samuel Omotoye

  • Julia McHugh

  • Richard Kuk

  • William Maddox

  • Brian Williamson

  • Michael Bestawros

  • Yaw Adjei-Poku

  • Michael Hoskins

  • Sandeep Nair

  • Sean Mazer

  • David Singh

  • Daniel Alyesh

  • Nicholas Palmeri

  • Nasir Shariff

  • Venkata Pendyala

  • Steven Levi

  • John Costello

  • George Mark

  • Parth Makker

  • Ganesh Venkataraman

  • Layth Saleh

  • Chaun Gandolfo

  • Ali Sheikh

  • Christopher Porterfield

  • Alexis Tumolo

  • Lohit Garg

  • Wendy Tzou

  • Matthew Zipse

  • Amneet Sandhu

  • Paul Varosy

  • Junaid Zaman

  • Andrew Zadeh

  • Steven Leung

  • Ivan Ho

  • Rodrigo Bolanos

  • Peter Farjo

  • Sergio Conti

  • Paari Dominic

  • Edward Powers

  • Parin Patel

  • Tariq Salam

  • Jeffrey Ho

  • Todd Senn

  • David Newton

  • Aleem Mughal

  • Matthew Quin

  • Lee Gemma

  • Kent Morris

  • Megan Gruber

  • Hassan Khan

  • Kevin Thomas

  • Kevin Parrott

  • Suresh Kulandhaisamy

  • Paban Saha

  • Michael Hushion

  • Zachary Hale

  • John Brandt

  • Jason Lappe

  • Michael Manogue

  • Jeffrey Senfield

  • Huy Phan

  • Sandeep Gautam

  • Rahul Jain

  • Jeffrey Arkles

  • Matthew Bernabei

  • Sandeep Bansal

  • Nils Guttenplan

  • Luigi Di Biase

  • Imdad Ahmed

  • Nicholas Costa

  • Adam Berman

  • Alfredo Pantano

  • Mouhannad Sadek

  • Yaariv Khaykin

  • Nischala Nannapaneni

  • An Bui

  • Andrew Corsello

  • Edward Sze

  • Henry Sesselberg

  • Jordan Leyton-Mange

  • Kunal Tandon

  • July 14, 2026

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Objective:

To analyze the independent association between diagnosis-to-ablation time (DAT) and recurrent atrial fibrillation (AF) following catheter ablation (CA) in a clinical practice population.

Approach:
  • Study Design: Prospective, multicenter registry (REAL-AF) enrolling participants undergoing radiofrequency or pulsed field ablation for symptomatic AF.
  • Participants: Adult patients with symptomatic AF; long-standing and persistent AF were excluded.
  • Data Collection: DAT defined as the earliest year of AF documentation; follow-up included ECGs and continuous rhythm monitoring.
  • Outcomes: Primary outcome was freedom from all atrial arrhythmia at 1-year follow-up; secondary outcomes included procedural characteristics and long-term clinical outcomes.
  • Statistical Analysis: Kaplan-Meier survival analysis and Cox proportional hazards models assessed the association between DAT and arrhythmia-free survival.
Key Findings:
  • AF recurrence occurs in 20% to 40% of cases within 1 year after CA.
  • DAT is an important predictor of procedural efficacy.
  • The study analyzed 8189 index ablations, with various exclusions for missing data.
Interpretation:

The findings suggest that a longer DAT may be associated with a higher likelihood of recurrent AF post-ablation. This indicates that timely intervention following AF diagnosis could enhance the effectiveness of ablation procedures. The results underscore the importance of early referral for catheter ablation in patients with symptomatic AF to potentially improve long-term outcomes.

Limitations:
  • The study's findings may be limited by its observational design, which can introduce biases. Additionally, the exclusion of patients with long-standing and persistent AF may affect the generalizability of the results. Missing data on some participants could also impact the robustness of the conclusions drawn regarding the relationship between DAT and AF recurrence.
Conclusion:

In conclusion, the study highlights the significance of DAT as a predictor of AF recurrence after catheter ablation, emphasizing the need for timely intervention to optimize patient outcomes. Further research is warranted to explore the mechanisms underlying this association and to establish optimal referral timelines for patients with AF. ---

Sources:

Original Source(s)

Diagnosis-to-Ablation Time and Atrial Arrhythmia Recurrence After Ablation

  • by Matthew J. Singleton, Christopher Thorne, Chang Dai, Daniela Hincapie, Daniel Campos-Villarreal, Susan M. Bezenek, Linda Justice, Allyson Varley, Obadah Aloum, Joshua Silverstein, Chinmaya Mareddy, Paul C. Zei, Bruce A. Koplan, Saumil Oza, Anil Rajendra, Matthew Sackett, Edmond Obeng Gmiyah, Matthew Sellers, Ghanshyam Shantha, Amit Thosani, Jefferson H. Lee, Jose Osorio, REAL-AF Investigators, Wai Tam, Srinivas Rajsheker, Alexandru Costea, Rajan Shah, Christopher Woods, Kavisha Patel, Rajat Goyal, Richard Hongo, Steven Kang, Amir Schricker, Smit Vasaiwala, Mohit Rastogi, Devi Nair, Jose Osorio Filho, Gustavo Morales, Francis Benn, Macy Smith, Karl Ilg, Joshua Greenberg, Waddah Maskoun, Arfaat Khan, Mark Lahiri, Mohamad Raad, Matthew Ebinger, Jeremiah Wasserlauf, Alex Ro, Jose Nazari, Mark Metzl, Sunil Vasireddi, Jennifer Wright, Christopher Purtell, Matthew Kalscheur, Ryan Kipp, Daniel Modaff, Blake Fleeman, Majid Mughal, Mohammad Kanjwal, Michael Rehorn, Alap Shah, Tharian Cherian, Emerson Liu, Charles Miller, William Belden, Mati Friehling, George C. Shaw, Subha Varahan, Charles Te, Sarah Levin, Ethan Hoch, David Steckman, Daniel Buerkel, Daniel Pelchovitz, Andrew Noll, Scott Ferreira, John Garner, Paul Zei, Bruce Koplan, Thomas Tadros, Jorge Romero, Nathaniel Steiger, Dinesh Sharma, Anthony Magnano, Benjamin D'Souza, Sandeep Goyal, Michael Hoosien, Kavita Krishnasamy, Ashish Bhimani, Javier Sanchez, Rajeev Joshi, Kamala Tamirisa, Sunil Reddy, Jodie Hurwitz, Brett Gidney, Edwin Zishiri, Bipin Ravindran, Shrinivas Hebsur, Mohammad-Ali Jazayeri, Xu Gao, Andrew Hughey, Asim Ahmed, Jonathan Dukes, Emmanuel Ekanem, Evan Martow, Kenneth Quadros, Kyle Murray, Antonio Moretta, Matthew Singleton, Edmond Obeng-Gyimah, Jefferson Lee, Jose Silva, Samuel Omotoye, Julia McHugh, Richard Kuk, William Maddox, Brian Williamson, Michael Bestawros, Yaw Adjei-Poku, Michael Hoskins, Sandeep Nair, Sean Mazer, David Singh, Daniel Alyesh, Nicholas Palmeri, Nasir Shariff, Venkata Pendyala, Steven Levi, John Costello, George Mark, Parth Makker, Ganesh Venkataraman, Layth Saleh, Chaun Gandolfo, Ali Sheikh, Christopher Porterfield, Alexis Tumolo, Lohit Garg, Wendy Tzou, Matthew Zipse, Amneet Sandhu, Paul Varosy, Junaid Zaman, Andrew Zadeh, Steven Leung, Ivan Ho, Rodrigo Bolanos, Peter Farjo, Sergio Conti, Paari Dominic, Edward Powers, Parin Patel, Tariq Salam, Jeffrey Ho, Todd Senn, David Newton, Aleem Mughal, Matthew Quin, Lee Gemma, Kent Morris, Megan Gruber, Hassan Khan, Kevin Thomas, Kevin Parrott, Suresh Kulandhaisamy, Paban Saha, Michael Hushion, Zachary Hale, John Brandt, Jason Lappe, Michael Manogue, Jeffrey Senfield, Huy Phan, Sandeep Gautam, Rahul Jain, Jeffrey Arkles, Matthew Bernabei, Sandeep Bansal, Nils Guttenplan, Luigi Di Biase, Imdad Ahmed, Nicholas Costa, Adam Berman, Alfredo Pantano, Mouhannad Sadek, Yaariv Khaykin, Nischala Nannapaneni, An Bui, Andrew Corsello, Edward Sze, Henry Sesselberg, Jordan Leyton-Mange, Kunal Tandon

  • July 14, 2026

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