Does Lithium Improve Agitation After Valproate in Schizophrenia? - Summary - MDSpire
From the Journals

Does Lithium Improve Agitation After Valproate in Schizophrenia?

Case report suggests benefit in behavioral symptoms with lithium augmentation following adverse events with adjunctive therapy.

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Lithium augmentation showed promise in reducing agitation and aggression in a 49-year-old female with treatment-resistant schizophrenia, previously treated with valproate that had to be discontinued due to hypoglycemia and pancytopenia. Initial valproate treatment resulted in improved irritability, but adverse effects prompted a transition to lithium. Following lithium administration, significant reductions in agitation and hostility were noted, alongside a decrease in overall psychiatric severity, though some psychotic symptoms persisted. This single-case study raises concerns regarding the role of mood stabilizers in managing residual-phase schizophrenia.

Original Source(s)

Does Lithium Improve Agitation After Valproate in Schizophrenia?

  • by Andrea Surnit

  • April 23, 2026

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