Representation is power: traditional, hybrid, and digital recruitment results from a non-randomized clinical trial engaging adolescents - Summary - MDSpire

Representation is power: traditional, hybrid, and digital recruitment results from a non-randomized clinical trial engaging adolescents

  • By

  • Taylor B. Harrison

  • Jessica A. Sinclair

  • Lisa J. Martin

  • Kristin Childers-Buschle

  • Holly Elder

  • Sunyang Fu

  • Hongfang Liu

  • William B. Brinkman

  • Melanie F. Myers

  • Michelle L. McGowan

  • October 7, 2025

  • 0 min

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Objective:

To demonstrate how a multipronged recruitment approach, which includes various strategies, can support more diverse trial engagement in a clinical trial involving adolescents and young adults.

Key Findings:
  • 39.1% of participants were enrolled through digital strategies, 34.2% through traditional methods, and 23.2% through targeted hybrid strategies.
  • Targeted hybrid recruitment had the largest proportion of participants from historically underrepresented groups (87.5%).
  • Traditional recruitment yielded 48.5% from underrepresented groups, while digital methods yielded 32.3%.
Interpretation:

The study highlights the effectiveness of integrating digital and traditional recruitment strategies to improve diversity in clinical trial participation, addressing historical biases in research representation.

Limitations:
  • The study is non-randomized, which may limit the generalizability of the findings due to potential selection biases.
  • Potential biases in self-reported demographic data.
Conclusion:

A multipronged recruitment approach can effectively increase diversity in clinical trials, counteracting the overrepresentation of participants of European descent and promoting equitable research outcomes.

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