Exercise Intervention on Sleep Quality in Alzheimer's Disease: A Systematic Review and Meta-Analysis - Summary - MDSpire

Exercise Intervention on Sleep Quality in Alzheimer's Disease: A Systematic Review and Meta-Analysis

  • By

  • Tan, Zelong

  • Jin, Yichen

  • Niu, Zhipei

  • April 27, 2026

  • 0 min

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Objective:

To evaluate the effect of exercise interventions on sleep quality in individuals with Alzheimer's disease.

Key Findings:
  • 12 RCTs involving 893 participants were included.
  • Exercise interventions significantly improved perceived sleep quality (SMD = -0.81, p=0.030).
  • No significant effects were found on objective sleep measures like sleep efficiency (SMD = -0.23, p=0.850) and total sleep duration (SMD = 0.25, p=0.530).
  • Greater benefits were observed in participants with baseline PSQI > 10 and those engaging in exercise sessions lasting ≥1 hour.
Interpretation:

Exercise may enhance subjective sleep quality in Alzheimer's patients, particularly in those with more severe sleep disturbances or longer exercise sessions.

Limitations:
  • Lack of significant findings on objective sleep metrics.
  • Need for larger-scale studies with rigorous methodologies.
Conclusion:

Exercise interventions may improve subjective sleep quality in Alzheimer's patients, but further research is needed to confirm objective benefits and determine optimal exercise protocols.

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