Perioperative mortality and 1-year neurodevelopmental outcome after cardiac surgery prior to 6 weeks of age, requiring perioperative extracorporeal membrane oxygenation in the first year of life - Summary - MDSpire
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Perioperative mortality and 1-year neurodevelopmental outcome after cardiac surgery prior to 6 weeks of age, requiring perioperative extracorporeal membrane oxygenation in the first year of life
To investigate perioperative mortality and the independent impact of ECMO on 1-year neurodevelopmental outcomes after cardiac surgery in infants younger than 6 weeks.
Approach:
Data Source: Data was collected from the Swiss Outcome Registry for Children with severe CHD (Swiss ORCHID).
Patient Population: 240 patients who underwent surgery between January 1, 2020, and May 30, 2024, were included.
Outcome Measures: 1-year mortality and neurodevelopmental outcomes were assessed using the Bayley Scales of Infant Development, Third Edition (BSID III).
Key Findings:
The 1-year mortality rate was 5.8%.
Mortality was significantly higher in the ECMO group (29.4%) compared to the non-ECMO group (1.9%).
Mean cognitive composite scores (CCS) and motor composite scores (MCS) were significantly lower in the ECMO group (p < 0.001).
Interpretation:
Perioperative ECMO is associated with higher mortality and lower neurodevelopmental scores in infants with congenital heart disease.
Limitations:
The study may not account for all potential confounding factors affecting neurodevelopmental outcomes.
Data was limited to a single registry, which may affect generalizability.
Conclusion:
Perioperative ECMO may be associated with higher mortality and lower neurodevelopmental scores in infants with congenital heart disease.
