Objective:

To examine the relationship between serum chloride levels and mortality in septic patients with liver cirrhosis, aiming to identify a prognostic indicator specifically for this population to improve patient outcomes.

Key Findings:

• Serum chloride levels exhibited a non-linear relationship with all-cause mortality in septic patients with liver cirrhosis, indicating that both low and high levels may increase risk.
• Mortality risk varied significantly across different quartiles of serum chloride concentrations.
• Both low and high serum chloride levels were associated with increased mortality risk at 30, 60, and 365 days.

Interpretation:

The findings suggest that serum chloride could serve as a valuable prognostic marker in septic patients with liver cirrhosis, indicating that both hypo- and hyperchloremia may adversely affect survival and warrant clinical attention.

Limitations:

• The study is observational and may be subject to confounding factors.
• Data derived from a single database may limit generalizability to broader populations.
• Potential biases in data extraction and analysis methods could affect results.
• The impact of missing data on the study's conclusions should be considered.

Conclusion:

Serum chloride concentrations are associated with mortality in septic patients with liver cirrhosis, highlighting the need for further research to validate these findings and explore therapeutic implications.