Contrast-enhanced mammography versus breast MRI in the preoperative evaluation of the nipple-areola complex: data from a real-world setting - Summary - MDSpire

Contrast-enhanced mammography versus breast MRI in the preoperative evaluation of the nipple-areola complex: data from a real-world setting

  • By

  • Michele Lorenzon

  • Paola Minichetti

  • Laura Casotto

  • Lorenzo Cereser

  • Chiara Zuiani

  • Rossano Girometti

  • February 24, 2026

  • 0 min

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Objective:

To compare the diagnostic performance of contrast-enhanced mammography (CEM) and breast MRI in the preoperative assessment of the Nipple-Areola Complex (NAC) in breast cancer patients, highlighting the importance of accurate NAC evaluation for surgical planning.

Key Findings:
  • CEM and MRI were performed on 195 women, with 91 undergoing CEM and 104 undergoing MRI. MRI demonstrated higher sensitivity (71%) and specificity (94%) for assessing NAC involvement compared to CEM, indicating its superior diagnostic capability.
Interpretation:

While MRI remains the gold standard for assessing NAC involvement in breast cancer, CEM may provide a useful alternative, particularly for older patients or those with contraindications to MRI, potentially influencing clinical decision-making.

Limitations:
  • The study's retrospective design may introduce selection bias, and the limited prior studies on CEM's accuracy for NAC assessment make comparisons challenging, which could affect the generalizability of the findings.
Conclusion:

CEM shows promise as an alternative imaging modality for preoperative assessment of NAC involvement in breast cancer, but further studies are needed to validate its diagnostic performance against MRI and to explore its role in clinical practice.

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