Intraoperative radiotherapy after neurosurgical resection of brain metastases as institutional standard treatment– update of the oncological outcome form a single center cohort after 117 procedures - Summary - MDSpire

Intraoperative radiotherapy after neurosurgical resection of brain metastases as institutional standard treatment– update of the oncological outcome form a single center cohort after 117 procedures

  • By

  • Klaus-Henning Kahl

  • Philipp E. Krauss

  • Maria Neu

  • Christoph J. Maurer

  • Sabine Schill-Reiner

  • Zoha Roushan

  • Eva Laukmanis

  • Christian Dobner

  • Tilman Janzen

  • Nikolaos Balagiannis

  • Björn Sommer

  • Georg Stüben

  • Ehab Shiban

  • July 4, 2024

  • 0 min

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Objective:

To evaluate the oncological outcomes and toxicity of intraoperative radiotherapy (IORT) after neurosurgical resection of brain metastases (BM) in a high-volume routine setting, emphasizing the importance of both aspects for comprehensive treatment assessment.

Key Findings:
  • 105 patients (117 resected BM) were treated with IORT, with findings contextualized to their clinical significance.
Interpretation:

IORT after resection of BM shows promising local control and overall survival rates, suggesting its effectiveness as a standard treatment in this setting, supported by existing literature.

Limitations:
  • Retrospective design may introduce selection bias, limited follow-up duration for some patients, and single-center study may limit generalizability, with explanations of how these factors could affect the results.
Conclusion:

IORT is a viable treatment option for patients undergoing resection of brain metastases, offering high local control rates and acceptable survival outcomes, with implications for its adoption as a standard treatment.

Original Source(s)

Intraoperative radiotherapy after neurosurgical resection of brain metastases as institutional standard treatment– update of the oncological outcome form a single center cohort after 117 procedures

  • by Klaus-Henning Kahl, Philipp E. Krauss, Maria Neu, Christoph J. Maurer, Sabine Schill-Reiner, Zoha Roushan, Eva Laukmanis, Christian Dobner, Tilman Janzen, Nikolaos Balagiannis, Björn Sommer, Georg Stüben, Ehab Shiban

  • July 4, 2024

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