Large language model-based uncertainty-adjusted label extraction for artificial intelligence model development in upper extremity radiography - Summary - MDSpire

Large language model-based uncertainty-adjusted label extraction for artificial intelligence model development in upper extremity radiography

  • By

  • Hanna Kreutzer

  • Anne-Sophie Caselitz

  • Thomas Dratsch

  • Daniel Pinto dos Santos

  • Christiane Kuhl

  • Daniel Truhn

  • Sven Nebelung

  • November 14, 2025

  • 0 min

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Objective:

To investigate the use of large language models (LLMs) for automated label extraction across multiple anatomic regions of the upper extremity and assess the impact of label uncertainty on model performance, specifically how it may influence classification accuracy.

Key Findings:
  • LLMs can accurately extract labels from radiologic reports while detecting uncertainty, which is crucial for improving model robustness.
  • Label uncertainty does not negatively impact model performance, suggesting that models can be trained effectively even with ambiguous labels.
  • Extracted labels facilitate efficient training of multi-label classification models, potentially leading to better diagnostic tools.
Interpretation:

The study demonstrates the potential of LLMs in enhancing the quality and quantity of data for AI model training in radiography, particularly in addressing label uncertainty, which could lead to more reliable AI applications in clinical settings.

Limitations:
  • The study is retrospective and may not account for all variables affecting label accuracy, which could introduce bias.
  • Only specific upper extremity regions were analyzed, limiting generalizability to other anatomical areas or conditions.
Conclusion:

LLMs provide a promising approach for automated, uncertainty-aware label extraction in radiology, potentially improving AI model training and performance.

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