Integrated single-cell and spatial transcriptomics reveal immune landscape and NKT–Th1 signatures in colorectal cancer - Summary - MDSpire

Integrated single-cell and spatial transcriptomics reveal immune landscape and NKT–Th1 signatures in colorectal cancer

  • By

  • Cunen Wu

  • Yuanyuan Xu

  • Ming Zhao

  • Lihuiping Tao

  • Dayue Darrel Duan

  • Jun Qian

  • Shumin Zhao

  • Shenlin Liu

  • Jin-yong Zhou

  • June 10, 2026

  • 0 min

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Objective:

To investigate immune-related signatures associated with response to immunotherapy in colorectal cancer (CRC) by analyzing NKT cell heterogeneity and its interactions with Th1 cells.

Approach:
    Key Findings:
    • Elevated NKT cell infiltration correlated with improved prognosis and enhanced immunotherapy sensitivity.
    • High NTRG scores were linked with worse overall survival but stronger immunotherapy response.
    • Differential NTRG expression was confirmed between normal and cancerous tissues and across immunotherapy responders and non-responders.
    Interpretation:

    Limitations:
    • The study is exploratory and requires further validation in larger cohorts.
    • The relationship between NTRG score and clinical outcomes needs more extensive investigation.
    Conclusion:

Original Source(s)

Integrated single-cell and spatial transcriptomics reveal immune landscape and NKT–Th1 signatures in colorectal cancer

  • by Cunen Wu, Yuanyuan Xu, Ming Zhao, Lihuiping Tao, Dayue Darrel Duan, Jun Qian, Shumin Zhao, Shenlin Liu, Jin-yong Zhou

  • June 10, 2026

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