Rapid prediction of cardiac activation in the left ventricle with geometric deep learning: a step towards cardiac resynchronization therapy planning - Summary - MDSpire

Rapid prediction of cardiac activation in the left ventricle with geometric deep learning: a step towards cardiac resynchronization therapy planning

  • By

  • Ehsan Naghavi

  • Haifeng Wang

  • Vahid Ziaei-Rad

  • Julius Guccione

  • Ghassan Kassab

  • Vishnu Boddeti

  • Seungik Baek

  • Lik-Chuan Lee

  • February 7, 2026

  • 0 min

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Objective:

To develop geometric deep learning models for predicting activation time maps on left ventricular geometries to improve planning for cardiac resynchronization therapy (CRT).

Key Findings:
  • GINO model achieved 1.38% error on synthetic cases compared to 2.44% for GNN.
  • Both models demonstrated comparable performance on real-world LV geometries (GINO: 4.79% vs GNN: 4.07%).
  • The models can recover ground-truth parameters from noisy inputs effectively.
Interpretation:

The study indicates that geometric deep learning can enhance the precision of CRT planning by providing real-time predictions of cardiac activation, potentially leading to better patient outcomes.

Limitations:
  • Models were trained on synthetic data, which may not fully capture the complexity of real patient anatomies.
  • Performance on diverse patient populations and varying clinical scenarios needs further validation.
Conclusion:

The developed models show promise for improving CRT planning through personalized pacing site identification, paving the way for future clinical decision-support tools.

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