Objective:

To evaluate long-term mortality trends among individuals with coexisting urinary tract cancers and diabetes from 1999 to 2024.

Key Findings:

• Deaths increased from 1,566 in 1999 to 4,487 in 2024.
• Age-adjusted mortality rate rose from 0.87 to 1.53 per 100,000 (AAPC 2.30%).
• Mortality surged during 2018–2021 (APC 9.93%) before leveling off.
• Men had higher mortality rates than women (AAPC 2.42% vs. 1.00%).
• The oldest age group (≥85 years) showed the largest increase in mortality (AAPC 3.61%).
• The South region had the highest increase in mortality (AAPC 3.57%).
• Nonmetropolitan areas had higher mortality levels and growth compared to metropolitan areas (AAPC 3.19% vs. 1.85%).
• Non-Hispanic White individuals experienced the greatest rise in mortality (AAPC 2.51%).

Interpretation:

Mortality from coexisting urinary tract cancers and diabetes rose substantially over two decades, with notable demographic and geographic disparities.

Limitations:

• The study relies on death certificate data, which may have inaccuracies.
• Potential confounding factors, such as socioeconomic status and comorbidities, were not accounted for in the analysis.

Conclusion:

Integrated prevention and management strategies are urgently needed to address the rising mortality trends in this population.