Clinical characteristics of lung abscess by red complex bacteria infection: a case report and literature review - Summary - MDSpire

Clinical characteristics of lung abscess by red complex bacteria infection: a case report and literature review

  • By

  • Zhiyang Xu

  • Lian Xu

  • Jinliang Liu

  • Lantian Pang

  • Lexin Xia

  • July 3, 2026

  • 0 min

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Objective:

To report a case of chronic lung abscess caused by red complex bacteria and review existing literature on the topic, highlighting the connection between oral health and respiratory infections.

Approach:
  • Case Presentation: A 63-year-old male with chronic cough and hemoptysis underwent diagnostic imaging and biopsy, leading to the identification of Treponema denticola and Porphyromonas gingivalis via metagenomic next-generation sequencing (mNGS).
  • Literature Review: A literature search was conducted to gather existing case reports and series related to lung abscesses caused by red complex bacteria.
Key Findings:
  • Treponema denticola and Porphyromonas gingivalis were identified as causative agents of a culture-negative lung abscess, emphasizing the link between oral health and respiratory infections.
  • mNGS proved effective in diagnosing fastidious anaerobes in lung infections.
  • The patient had a history of severe periodontitis.
Interpretation:

This case illustrates the role of oral red complex bacteria in lung abscesses and the utility of mNGS in their identification.

Limitations:
  • The study is based on a single case report, which limits the generalizability of the findings.
  • Further research is needed to establish broader clinical implications and treatment protocols.
Conclusion:

This case highlights the role of oral pathogens in lung abscess diagnoses in patients with periodontitis.

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