To describe tumor histology-detected H. pylori positivity, characterize associated clinicopathological features, and explore the relationship between H. pylori status and overall survival in gastric cancer patients.
Approach:
Statistical Analysis: Survival estimation was performed using the Kaplan–Meier method, and comparisons were made using the log-rank test according to H. pylori status and initial management strategy. Exploratory multivariable Cox regression analyses were conducted to assess the relationship between H. pylori status and overall survival.
Key Findings:
Out of 82 patients, 43 (52.4%) were H. pylori-positive.
H. pylori positivity was significantly associated with non-active chronic gastritis.
No association was found between H. pylori status and tumor location, histological subtype, differentiation, or preneoplastic lesions.
Overall survival did not differ between H. pylori-positive and H. pylori-negative patients.
Initial management strategy was strongly associated with patient outcomes.
Interpretation:
Limitations:
Incomplete TNM staging limited interpretation of results.
H. pylori detection was based on routine histopathology, which may not reflect true infection prevalence.
Conclusion:
Routine histology detected H. pylori in about half of gastric tumors, with an association with non-active chronic gastritis, but it was not linked to survival outcomes.
