Objective:

To investigate the association of clinical characteristics and lipid metabolism parameters with adverse prognosis in patients hospitalized for acute decompensated heart failure (HF) with preserved or reduced left ventricular ejection fraction (LVEF).

Approach:

Key Findings:

• Significant differences in clinical symptoms and clinical characteristics between HFpEF and HFrEF groups.
• Multivariate logistic regression indicated that high levels of HDL-C have discriminatory ability in prognosis assessment (OR = 0.265, p = 0.038).
• The AUC value for HDL-C in prognosis assessment was 0.611 (p = 0.021).

Interpretation:

Clinical indicators of congestion, psychological distress, blood pressure load, total cholesterol, and HDL-C are associated with adverse prognosis in acute decompensated HF.

Limitations:

• The study is limited to a single hospital and may not be generalizable.
• Further studies are needed to explore dynamic changes in HDL-C and its role as a metabolic biomarker.

Conclusion:

Higher HDL-C shows modest but independent prognostic value in acute HF, particularly in HFpEF.

Attribution Notice

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.