Effectiveness of structured nursing interventions in reducing complication related morbidity in leukemia patients undergoing hematopoietic stem cell transplantation - Summary - MDSpire
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Effectiveness of structured nursing interventions in reducing complication related morbidity in leukemia patients undergoing hematopoietic stem cell transplantation
To evaluate the effectiveness of a multifaceted structured nursing intervention program in reducing complication-related morbidity among leukemia patients undergoing autologous or allogeneic HSCT.
Approach:
Intervention: The structured nursing intervention included comprehensive pre-transplant education, strict infection prevention bundles, scheduled oral mucosal care, gastrointestinal and nutritional support, skin care protocols, GVHD surveillance for allogeneic recipients, psychosocial support, and a daily structured assessment checklist.
Key Findings:
Febrile neutropenia decreased from 64.2% to 37.7% (p = 0.002).
Oral mucositis Grade ≥2 decreased from 54.7% to 28.3% (p = 0.001).
Documented infections decreased from 49.1% to 26.4% (p = 0.004).
Acute GVHD decreased from 41.9% to 24.2% (p = 0.031).
Severe diarrhea decreased from 34.0% to 17.0% (p = 0.018).
Skin complications decreased from 28.3% to 13.2% (p = 0.022).
Hospital length of stay decreased from 28.6 ± 6.4 to 23.2 ± 5.1 days (p = 0.001).
ICU admissions reduced from 22.6% to 11.3% (p = 0.041).
30-day readmission rates fell from 18.9% to 8.5% (p = 0.038).
