Adenovirus Types in US Children Hospitalized or Seen in the Emergency Department With Acute Respiratory Illness, 2016–2019 - Summary - MDSpire

Adenovirus Types in US Children Hospitalized or Seen in the Emergency Department With Acute Respiratory Illness, 2016–2019

  • By

  • Tess Stopczynski

  • Varvara Probst

  • Adam Gailani

  • Justin Z Amarin

  • Olla Hamdan

  • Haya Hayek

  • Laura S Stewart

  • Herdi K Rahman

  • Rangaraj Selvarangan

  • Jennifer E Schuster

  • Christopher J Harrison

  • Mary E Moffatt

  • Marian G Michaels

  • John V Williams

  • Julie A Boom

  • Leila C Sahni

  • Vasanthi Avadhanula

  • Mary Allen Staat

  • Elizabeth P Schlaudecker

  • Christina Quigley

  • Geoffrey A Weinberg

  • Peter G Szilagyi

  • Janet A Englund

  • Eileen J Klein

  • Aaron T Curns

  • Heidi L Moline

  • Ariana P Toepfer

  • James D Chappell

  • Andrew J Spieker

  • Natasha B Halasa

  • November 12, 2025

  • 0 min

Share

Objective:

To characterize human adenovirus (HAdV) types and their association with clinical presentations and outcomes in pediatric patients with acute respiratory illness (ARI), emphasizing the importance of understanding these variations.

Key Findings:
  • Among 1843 HAdV-positive cases, 1402 specimens (76%) were typed.
  • Most common types detected were HAdV-C1 (439 cases), HAdV-C2 (393 cases), and HAdV-B3 (221 cases).
  • Children with HAdV-B7 had higher odds of severe outcomes compared to other types (aOR = 2.05; 95% CI: 1.24, 3.40).
  • Symptom presentation varied across HAdV types, with species B showing higher frequency of non-respiratory symptoms, indicating the need for type-specific clinical considerations.
Interpretation:

The study highlights the heterogeneity in clinical presentation and severity among different HAdV types, particularly emphasizing the need for type-specific considerations in prevention and treatment strategies, which could significantly impact clinical outcomes.

Limitations:
  • The study was limited to specific pediatric medical centers, which may affect generalizability and the applicability of findings to broader populations.
  • Enrollment restrictions in the emergency department may have influenced the demographic representation, potentially skewing results.
Conclusion:

Understanding the specific contributions of individual HAdV types to clinical severity and outcomes can inform targeted interventions and improve management of pediatric ARI, highlighting the necessity for further research on HAdV types.

Original Source(s)

Adenovirus Types in US Children Hospitalized or Seen in the Emergency Department With Acute Respiratory Illness, 2016–2019

  • by Tess Stopczynski, Varvara Probst, Adam Gailani, Justin Z Amarin, Olla Hamdan, Haya Hayek, Laura S Stewart, Herdi K Rahman, Rangaraj Selvarangan, Jennifer E Schuster, Christopher J Harrison, Mary E Moffatt, Marian G Michaels, John V Williams, Julie A Boom, Leila C Sahni, Vasanthi Avadhanula, Mary Allen Staat, Elizabeth P Schlaudecker, Christina Quigley, Geoffrey A Weinberg, Peter G Szilagyi, Janet A Englund, Eileen J Klein, Aaron T Curns, Heidi L Moline, Ariana P Toepfer, James D Chappell, Andrew J Spieker, Natasha B Halasa

  • November 12, 2025

Related Content

Analysis of the epidemic situation of respiratory pathogens in central and southern China before and after the COVID-19 pandemic

Manufacturability is access: redesigning antibody production for equitable pediatric access in LMICs

HPV vaccine hesitancy among Chinese adults and its influencing factors in the context of improved vaccine accessibility