Brain Imaging and Whole Blood Targeted Transcriptomic Analyses to Characterize Cerebral Infarctions in Children With Tuberculous Meningitis - Summary - MDSpire

Brain Imaging and Whole Blood Targeted Transcriptomic Analyses to Characterize Cerebral Infarctions in Children With Tuberculous Meningitis

  • By

  • Julie Huynh

  • Pieter M Pretorius

  • Wajanat Jan

  • Carolina Kachramanoglou

  • Nhat Hoang Thanh Le

  • Van La Ngoc

  • Hai Thanh Hoang

  • Ny Thi Hong Tran

  • Tram Ngoc Pham

  • Thu Anh Dang Do

  • Dung Thi Mong Vu

  • Trinh Thi Bich Tram

  • Do Dinh Vinh

  • Tung Huu Trinh

  • Nguyen Dinh Qui

  • Minh Ha Thi Dang

  • Elena Frangou

  • Sierra Santana

  • Caitlin Muller

  • Suzanne T Anderson

  • Diana M Gibb

  • Nhung Thi Hong Nguyen

  • Nguyen Thuy Thuong Thuong

  • Guy Thwaites

  • on behalf of the SURE Trial Team

  • August 2, 2025

  • 0 min

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Objective:

To characterize cerebral infarction in children with tuberculous meningitis and explore its relationship with systemic inflammatory mediators, emphasizing the significance of this relationship for understanding disease outcomes.

Key Findings:
  • 73% of children had mild disease and 63% had cerebral infarctions, with statistical significance noted.
  • Cerebral infarctions were commonly acute (47%), multiple (74%), and bilateral (63%), with statistical significance noted.
  • Infarctions predominantly affected cerebral hemispheres (59%), basal ganglia (53%), and thalamus (26%), with statistical significance noted.
  • Children with infarctions had higher cerebrospinal fluid protein and lower glucose levels, along with increased systemic MMP-8 expression, with statistical significance noted.
Interpretation:

Cerebral infarctions in pediatric tuberculous meningitis are associated with systemic inflammation, which may contribute to poor neurological outcomes, warranting further investigation into the mechanisms involved.

Limitations:
  • The study was conducted in a single center, which may limit generalizability and introduce potential biases.
  • The sample size may not be large enough to draw definitive conclusions, suggesting the need for larger multi-center studies.
Conclusion:

Understanding the inflammatory mechanisms associated with cerebral infarctions in TBM may guide the development of more effective therapies, particularly in targeting systemic inflammation.

Original Source(s)

Brain Imaging and Whole Blood Targeted Transcriptomic Analyses to Characterize Cerebral Infarctions in Children With Tuberculous Meningitis

  • by Julie Huynh, Pieter M Pretorius, Wajanat Jan, Carolina Kachramanoglou, Nhat Hoang Thanh Le, Van La Ngoc, Hai Thanh Hoang, Ny Thi Hong Tran, Tram Ngoc Pham, Thu Anh Dang Do, Dung Thi Mong Vu, Trinh Thi Bich Tram, Do Dinh Vinh, Tung Huu Trinh, Nguyen Dinh Qui, Minh Ha Thi Dang, Elena Frangou, Sierra Santana, Caitlin Muller, Suzanne T Anderson, Diana M Gibb, Nhung Thi Hong Nguyen, Nguyen Thuy Thuong Thuong, Guy Thwaites, on behalf of the SURE Trial Team

  • August 2, 2025

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