Objective:

To explore the risk factors associated with bleeding in atrial fibrillation patients undergoing PCI, specifically comparing those receiving dual therapy (ticagrelor + warfarin) to those on triple therapy (clopidogrel + aspirin + warfarin).

Key Findings:

• Overall bleeding incidence at 6 months was 36.49% in the dual group and 35.62% in the triple group (P > 0.05), indicating no significant difference between groups.
• Alcohol consumption was positively correlated with overall bleeding (OR = 3.905, P = 0.001), highlighting a significant risk factor.
• Age was positively associated with bleeding risk (OR = 1.059, P = 0.032), suggesting that older patients are at higher risk.
• Lower body mass index was negatively associated with bleeding risk in the triple therapy group (OR = 0.911, P = 0.048), indicating a complex relationship.

Interpretation:

Alcohol consumption and aging are significant risk factors for bleeding in atrial fibrillation patients post-PCI. Additionally, lower body weight increases risk in those on triple therapy, necessitating careful management.

Limitations:

• The study is limited by its observational nature and reliance on self-reported alcohol consumption, which may introduce bias.
• The sample size may not fully represent the broader atrial fibrillation population, potentially limiting the generalizability of the findings.

Conclusion:

Individualized anticoagulation management should consider alcohol consumption, age, and body weight to effectively mitigate bleeding risks in atrial fibrillation patients post-PCI.