To compare the risk of developing metabolic syndrome (MetSyn) in patients with hyperandrogenic polycystic ovary syndrome (PCOS) with and without a history of depression and/or anxiety.
Key Findings:
33.0% of participants had a history of depression and/or anxiety.
Depression and/or anxiety increased the risk of developing MetSyn (adjusted hazard ratio [aHR] 1.45, 95% CI 1.02-2.06).
Incidence of MetSyn was 75.3 cases per 100 person-years in those with depression/anxiety compared to 47.6 in those without (P = .002).
The association was stronger for depression (aHR 1.56, 95% CI 1.10-2.20).
Interpretation:
Women with PCOS and a history of depression and/or anxiety are at a significantly higher risk of developing MetSyn, emphasizing the need for mental health screening in this population.
Limitations:
Retrospective design may limit causal inferences.
Study population primarily consisted of women from a single center, potentially affecting generalizability and diversity.
Conclusion:
The findings highlight the importance of screening for depression and anxiety in women with PCOS to facilitate metabolic monitoring and early intervention in this high-risk group.
