Putting a POC Troponin to the Test - Summary - MDSpire

Putting a POC Troponin to the Test

Independent verification shows strong precision and concordance with lab assays across clinical thresholds.

  • By

  • Julie Greenbaum

  • February 5, 2026

  • 3 min

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Objective:

To verify the analytical performance and concordance of the QuidelOrtho TriageTrue point-of-care high-sensitivity troponin I assay in patients assessed for myocardial infarction.

Key Findings:
  • Intra-assay precision CVs were 25% and 12.2% at mean concentrations of 2.4 ng/L and 8.5 ng/L, respectively, with overall performance metrics indicating adequacy.
  • Hemolysis caused minimal interference up to 10 g/L, exceeding the manufacturer's claim.
  • Correlation coefficients with other assays ranged from 0.89 to 0.99, except for Roche hs-TnT assay (0.79).
  • All 116 comparisons with secondary analyzers met acceptable limits.
Interpretation:

The hs-TnI assay on the TriageTrue demonstrates adequate performance for clinical use, supporting its integration into clinical pathways based on the findings.

Limitations:
  • Logistical constraints in obtaining suitable whole blood EDTA samples limited targeted sampling at specific troponin I levels, impacting the study's findings.
Conclusion:

The assay's analytical performance supports its use in emergency care and low-resource settings, aligning with manufacturer claims and emphasizing its clinical significance.

Original Source(s)

Putting a POC Troponin to the Test

  • by Julie Greenbaum

  • February 5, 2026

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