Objective:

To assess the effects of Chlorella vulgaris supplementation on cardiovascular disease (CVD) risk factors in patients with Non-Alcoholic Fatty Liver Disease (NAFLD) using a systematic review and meta-analysis approach.

Key Findings:

• C. vulgaris supplementation may improve lipid metabolism, insulin sensitivity, and inflammatory biomarkers in NAFLD patients.
• The study identified a gap in literature regarding the effects of C. vulgaris on CVD risk factors specifically in NAFLD patients.
• The use of GRADE provided a structured evaluation of the quality of evidence.

Interpretation:

C. vulgaris supplementation shows potential benefits for improving health outcomes related to CVD risk factors in individuals with NAFLD, but further research is needed to confirm these findings and understand the underlying mechanisms.

Limitations:

• The included studies were conducted between 2012 and 2017, prior to the nomenclature update from NAFLD to MASLD.
• Limited long-term data on the effects of C. vulgaris supplementation.

Conclusion:

This systematic review and meta-analysis highlights the potential role of C. vulgaris in supporting cardiovascular health in patients with NAFLD, warranting further investigation.