Impact of Preoperative Suspension of Antiplatelet Therapy on Thrombotic Events Following Minimally Invasive Surgery for Abdominopelvic Cancer in Patients Using P2Y12 Inhibitors - Summary - MDSpire

Impact of Preoperative Suspension of Antiplatelet Therapy on Thrombotic Events Following Minimally Invasive Surgery for Abdominopelvic Cancer in Patients Using P2Y12 Inhibitors

  • By

  • Masashi Kubota

  • Satomi Yoshida

  • Takayuki Goto

  • Toshiki Fukasawa

  • Takayuki Anno

  • Gaku Fujiwara

  • Satoshi Toshiyama

  • Yoshihide Inayama

  • Takanori Yanai

  • Takayuki Sumiyoshi

  • Ryoichi Saito

  • Takashi Kobayashi

  • Koji Kawakami

  • January 16, 2026

  • 0 min

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Objective:

To compare the effects of preoperative discontinuation versus maintenance of P2Y12 inhibitors on specific postoperative thrombotic complications during minimally invasive radical surgery for abdominopelvic cancers.

Key Findings:
  • Preoperative discontinuation of P2Y12 inhibitors was associated with an increased risk of thrombotic events post-surgery, with statistical significance.
  • Patients who maintained P2Y12 therapy showed better outcomes regarding thrombotic complications.
Interpretation:

The findings suggest that maintaining P2Y12 inhibitors may reduce the risk of thrombotic events in patients undergoing minimally invasive surgery for abdominopelvic cancers, challenging current guidelines that recommend discontinuation and highlighting the need for reevaluation in clinical practice.

Limitations:
  • Observational study design may introduce confounding factors and biases.
  • Data limited to specific hospitals and may not be generalizable.
Conclusion:

Maintaining P2Y12 inhibitors preoperatively may be safer for patients undergoing minimally invasive surgery for cancer, warranting further prospective studies to validate these findings and inform clinical guidelines.

Original Source(s)

Impact of Preoperative Suspension of Antiplatelet Therapy on Thrombotic Events Following Minimally Invasive Surgery for Abdominopelvic Cancer in Patients Using P2Y12 Inhibitors

  • by Masashi Kubota, Satomi Yoshida, Takayuki Goto, Toshiki Fukasawa, Takayuki Anno, Gaku Fujiwara, Satoshi Toshiyama, Yoshihide Inayama, Takanori Yanai, Takayuki Sumiyoshi, Ryoichi Saito, Takashi Kobayashi, Koji Kawakami

  • January 16, 2026

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