Objective:

To investigate the correlations between hepatic fat fraction (HFF) and ALT, GGT, and AST levels in colorectal cancer patients treated with FOLFOX4 chemotherapy using IDEAL-IQ MRI, highlighting the clinical significance of these correlations.

Key Findings:

• Significant correlation between hepatic fat fraction (HFF) and ALT, GGT, and AST levels in chemotherapy patients, with p-values indicating statistical significance.
• IDEAL-IQ MRI provided accurate and reproducible measurements of hepatic steatosis.
• Chemotherapy-induced liver injury was prevalent among patients undergoing FOLFOX4 treatment.

Interpretation:

The study supports the use of IDEAL-IQ MRI as a reliable non-invasive method to monitor liver fat content and its association with liver enzyme levels in colorectal cancer patients post-chemotherapy.

Limitations:

• Retrospective design may introduce selection bias; future studies should consider a prospective design.
• Limited sample size may affect generalizability of results; larger multi-center studies are recommended.
• Single-center study limits broader applicability; future research should include diverse populations.

Conclusion:

IDEAL-IQ MRI is a promising tool for assessing hepatic steatosis in colorectal cancer patients, potentially aiding in the management of chemotherapy-induced liver injury, and warrants further investigation in clinical settings.