The efficacy of acupuncture for depression-associated chronic pain: a systematic review and meta-analysis - Summary - MDSpire

The efficacy of acupuncture for depression-associated chronic pain: a systematic review and meta-analysis

  • By

  • Hui Zhao

  • Yuan Gao

  • Kun Zhang

  • Cheng Tang

  • Weidong Shen

  • June 1, 2026

  • 0 min

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Objective:

To determine the efficacy and safety of acupuncture in treating depression-associated chronic pain (DACP).

Key Findings:
  • Ten randomized controlled trials involving 761 participants were included.
  • Acupuncture combined with conventional medications was more effective than medication alone in improving depressive symptoms (SMD: -0.72; P < 0.01) and reducing pain (SMD: -0.85; P < 0.01).
  • Acupuncture showed similar effects to medication in improving Hamilton Depression Rating Scale scores (SMD: -0.05; P > 0.05) and Visual Analogue Scale scores (SMD: -0.33; P > 0.05).
  • Acupuncture had a better safety profile (relative risk: 0.40; 95% CI: 0.27 to 0.60).
  • A 4-week acupuncture treatment was found to be superior in improving depressive symptoms, while longer-term treatment was more effective for pain relief.
Interpretation:

Remove unsupported phrases and conclusions.

Limitations:
  • Limited number of studies included in the meta-analysis.
  • Variability in treatment duration and methodologies across studies.
Conclusion:

Remove unsupported claims and ensure it reflects only what is stated in the source.

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