Objective:

To evaluate the comparative safety and efficacy of remimazolam and propofol in gynecological procedural sedation.

Approach:

Key Findings:

• Remimazolam demonstrated a safety profile compared to propofol, with lower rates of overall adverse events, respiratory depression, and hypotension.
• Discrepancies in data extraction and outcome definitions were noted, particularly regarding hypotension and oxygen desaturation events.
• The classification of intervention arms may introduce clinical heterogeneity, particularly with combination regimens.

Interpretation:

Limitations:

• Omission of relevant data from certain studies limits interpretability.
• Variability in study designs and intervention protocols may affect generalizability.
• Insufficient evaluation of the certainty of findings and potential biases in pooled estimates.

Conclusion:

Sources:

• Frontiers in Medicine
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