Objective:

To reach consensus on the evaluation of rapid diagnostic tests (RDTs), molecular test standards, and cost-effectiveness frameworks for Chagas disease diagnostics.

Approach:

Key Findings:

• A total of 57% of experts participated in the pre-meeting survey, indicating strong preliminary consensus.
• The scoping review identified 41 RDTs, with sensitivities ranging from 90.1% to 100% and specificities from 95.5% to 100%.
• The harmonized RDT protocol was published by PAHO as the first standardized guideline for Chagas disease RDT evaluation.

Interpretation:

The meeting facilitated the development of standardized approaches to improve Chagas disease diagnostics, addressing gaps in current guidelines.

Limitations:

• The meeting's outcomes are based on expert consensus and may not encompass all perspectives.
• The effectiveness of the proposed protocols and guidelines will depend on their implementation in diverse healthcare settings.

Conclusion:

The expert meeting successfully established a framework for enhancing Chagas disease diagnostics through standardized evaluation and cost-effectiveness assessment.

Sources:

• PAHO
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