Biomarkers of pulmonary fibrosis in bronchoalveolar lavage fluid and saliva. Study methods and pathophysiological significance - Summary - MDSpire

Biomarkers of pulmonary fibrosis in bronchoalveolar lavage fluid and saliva. Study methods and pathophysiological significance

  • By

  • Cecilia Ángel-Reimúndez

  • Manuel F. Ruibal-Caballero

  • Virginia Leiro-Fernández

  • Milenis Salgado-Arteta

  • Lucas C. González-Matías

  • Alberto Fernández-Villar

  • Federico Mallo

  • May 25, 2026

  • 0 min

Share

Objective:

To synthesize the evidence on molecular markers in BALF and saliva relevant for the diagnosis and prognosis of lung diseases.

Key Findings:
  • BALF extraction is useful for analyzing lung diseases, allowing for the identification of microorganisms and inflammatory cells.
  • Saliva is an increasingly relevant biological fluid for quantifying biomarkers due to its ease of collection and potential for repeated sampling.
  • There is a lack of studies analyzing BALF and saliva simultaneously in the same patient cohorts.
Interpretation:

The review identifies knowledge gaps in the analysis of BALF and saliva biomarkers.

Limitations:
  • No studies have simultaneously analyzed BALF and saliva in the same patient cohorts.
  • Lack of standardized protocols for sampling, analytical normalization, and salivary reference ranges.
Conclusion:

The review discusses the need for further research in BALF and saliva biomarker analysis.

Original Source(s)

Biomarkers of pulmonary fibrosis in bronchoalveolar lavage fluid and saliva. Study methods and pathophysiological significance

  • by Cecilia Ángel-Reimúndez, Manuel F. Ruibal-Caballero, Virginia Leiro-Fernández, Milenis Salgado-Arteta, Lucas C. González-Matías, Alberto Fernández-Villar, Federico Mallo

  • May 25, 2026

Related Content

Top 10 States With Rising Demand for Physicians

These 10 states report physician shortages, projected physician supply gaps, or physician-to-population ratios below national benchmarks.

Pediatric pleural empyema - decision making beyond imaging - a retrospective cohort study

AD Not Linked to Early CV Risk Markers

Repeated assessments from childhood to early adulthood did not identify consistent cardiometabolic risk patterns by disease activity or severity.