Objective:

To explore cholinergic regulation of neuroinflammation through microglial activity, immune metabolism, and neural regulation.

Approach:

Key Findings:

• Neuroinflammation is a core pathological process in various neurological diseases.
• Microglia are key mediators of neuroinflammation and exhibit heterogeneous activation states.
• Cholinergic signaling influences microglial activity and inflammatory responses.
• Metabolic reprogramming in microglia is linked to cholinergic signaling and immune responses.
• Therapeutic strategies include targeting cholinergic pathways and vagus nerve stimulation.

Interpretation:

This review integrates cholinergic biology, microglial heterogeneity, and metabolic reprogramming to enhance understanding of neuroinflammation.

Limitations:

• The complexity of microglial activation states complicates understanding of cholinergic signaling effects.
• Further research is needed to elucidate mechanisms linking cholinergic signaling and immune metabolism.

Conclusion:

Reexamining the cholinergic anti-inflammatory framework from a CNS-centric perspective may provide insights into disease mechanisms.

Attribution Notice

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.