Testing Atropine’s Posterior Effects - Summary - MDSpire

Testing Atropine’s Posterior Effects

Low-dose atropine shows limited short-term posterior structural effects in young adults

  • June 12, 2026

  • 3 min

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Objective:

To explore the acute effects of low-concentration atropine on axial length, retinal thickness, choroidal thickness, and retinal perfusion in young adults.

Approach:
    Key Findings:
    • No significant changes in axial length, retinal thickness, or choroidal thickness were observed at one hour or 24 hours post-atropine instillation.
    • A transient reduction in superficial vascular complex perfusion density was noted one hour after atropine instillation.
    • No concentration-dependent effects were detected.
    Interpretation:

    Single-dose low-concentration atropine has minimal acute effects on posterior segment structure in young adults, although it may induce transient vascular changes.

    Limitations:
    • The study assessed only single-dose effects.
    • The cohort size was relatively small and did not include children, the primary population for myopia control.
    Conclusion:

    Further research is needed to evaluate long-term effects of repeated atropine exposure.

Original Source(s)

Testing Atropine’s Posterior Effects

  • June 12, 2026

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