Autologous stem cell transplantation for pediatric solid tumors in a resource-limited setting: a single-center experience of 15 years - Summary - MDSpire
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Autologous stem cell transplantation for pediatric solid tumors in a resource-limited setting: a single-center experience of 15 years
To assess survival outcomes, engraftment kinetics, and toxicities of autologous stem cell transplantation (ASCT) for pediatric solid tumors in a resource-constrained setting.
Key Findings:
Median age of patients was 6 years, with 69.6% being male.
3-year overall survival (OS) for the entire cohort was 50.6%, and event-free survival (EFS) was 35.9%.
3-year OS rates for specific diagnoses were: HRNB (48.5%), relapsed/refractory EWS (43.8%), relapsed/refractory GCT (56.3%), STS (66.7%), and RB (50.0%).
BuMel-140 conditioning regimen showed better OS compared to CEM-200 for HRNB and EWS.
Interpretation:
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Limitations:
Study is retrospective and conducted at a single center, which may limit generalizability.
Limited data on long-term outcomes and transplant-related complications in the context of resource constraints.
Conclusion:
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