HLA matching in contemporary haematopoietic cell transplantation: Recommendations from the EBMT Practice Harmonisation and Guidelines Committee - Summary - MDSpire

HLA matching in contemporary haematopoietic cell transplantation: Recommendations from the EBMT Practice Harmonisation and Guidelines Committee

  • By

  • Esteban Arrieta-Bolaños

  • Alberto Cardoso Martins Lima

  • Marco Andreani

  • Dianne De Santis

  • Florent Malard

  • Neema P. Mayor

  • Rohtesh S. Mehta

  • Roland Meisel

  • Simona Pagliuca

  • Effie Petersdorf

  • Simona Piemontese

  • Nicoletta Sacchi

  • Nicole Santoro

  • Jaime Sanz

  • Johannes Schetelig

  • Stephen R. Spellman

  • Francesco Onida

  • Isabel Sánchez-Ortega

  • Mohamad Mohty

  • Ibrahim Yakoub-Agha

  • Katharina Fleischhauer

  • Annalisa Ruggeri

  • June 2, 2026

  • 0 min

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Objective:

To provide evidence-based recommendations on the role of HLA in hematopoietic cell transplantation (HCT) based on recent advances in typing technologies, supportive care, and clinical practices.

Key Findings:
  • HLA mismatches are associated with inferior survival, but recent advances in GvHD prevention strategies have prompted a reevaluation of their relevance in contemporary HCT.
  • The frequency of HLA-mismatched transplantation has increased significantly due to improved GvHD prevention strategies, highlighting the evolving landscape of donor selection.
  • Non-HLA factors, such as donor age and other immunogenetic considerations, play a significant role in donor selection and may influence transplant outcomes.
Interpretation:

The expert consensus indicates that while HLA matching remains important, its relative significance may be changing due to advancements in transplantation techniques, such as improved GvHD prophylaxes and supportive care strategies.

Limitations:
  • The recommendations are based on consensus and may not cover all individual patient scenarios, particularly those with unique clinical presentations.
  • Further research is needed to address unanswered questions regarding HLA compatibility and outcomes, especially in diverse patient populations.
Conclusion:

The document summarizes expert consensus on HLA compatibility in HCT, aiming to guide clinical decision-making.

Original Source(s)

HLA matching in contemporary haematopoietic cell transplantation: Recommendations from the EBMT Practice Harmonisation and Guidelines Committee

  • by Esteban Arrieta-Bolaños, Alberto Cardoso Martins Lima, Marco Andreani, Dianne De Santis, Florent Malard, Neema P. Mayor, Rohtesh S. Mehta, Roland Meisel, Simona Pagliuca, Effie Petersdorf, Simona Piemontese, Nicoletta Sacchi, Nicole Santoro, Jaime Sanz, Johannes Schetelig, Stephen R. Spellman, Francesco Onida, Isabel Sánchez-Ortega, Mohamad Mohty, Ibrahim Yakoub-Agha, Katharina Fleischhauer, Annalisa Ruggeri

  • June 2, 2026

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