Influencing factors of cognitive frailty in older patients with esophageal cancer undergoing chemotherapy: a mixed-methods study - Summary - MDSpire

Influencing factors of cognitive frailty in older patients with esophageal cancer undergoing chemotherapy: a mixed-methods study

  • By

  • Fan Wang

  • Zhie Gu

  • Yixin Jia

  • Yuhui Li

  • Quan Mao

  • Yusheng Shu

  • June 16, 2026

  • 0 min

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Objective:

To examine the prevalence of cognitive frailty and its associated factors among older patients with esophageal cancer undergoing chemotherapy, and to provide evidence for the development of targeted nursing interventions.

Approach:
    Key Findings:
    • The incidence of cognitive frailty among older patients with esophageal cancer undergoing chemotherapy was 45.1%.
    • Significant factors associated with cognitive frailty included chemotherapy cycles, nutritional risk, sleep disturbances, depression, educational attainment, participation in cognitive training activities, and social support (p < 0.05).
    Interpretation:

    Cognitive frailty is relatively common among older patients undergoing chemotherapy for esophageal cancer and is influenced by multiple interrelated factors.

    Limitations:
    • The study used a convenience sample, which may limit generalizability.
    • The cross-sectional design does not allow for causal inferences.
    Conclusion:

    Healthcare professionals should strengthen assessment and management during chemotherapy and develop targeted interventions to reduce the risk of cognitive frailty.

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