Objective:

To synthesize existing evidence on the incidence of AKI following surgery for TAAD and its primary risk factors.

Approach:

Key Findings:

• A total of 44 studies were included, with a total sample size of 11,983 patients, of whom 6,115 developed AKI.
• Overall incidence of postoperative AKI following TAAD was 50.72%.
• Higher incidence rates were observed when diagnosed using KDIGO criteria compared to AKIN and RIFLE criteria.
• Incidence rates were higher in Chinese studies compared to non-Chinese studies.
• Significant risk factors for AKI included age, male gender, BMI, history of hypertension, preoperative serum creatinine, leukocyte count, lactate, renal artery involvement, cardiopulmonary bypass time, operative time, deep hypothermic circulatory arrest time.

Interpretation:

The study highlights a high incidence of AKI following TAAD surgery, emphasizing the need for awareness of multiple significant risk factors.

Limitations:

• Variability in sample size and AKI diagnostic criteria across studies.
• Potential biases in study selection and data extraction may affect the findings.

Conclusion:

A comprehensive prevention and control system covering preoperative assessment, intraoperative protection, and postoperative monitoring is recommended to reduce AKI incidence and improve patient outcomes.

Sources:

• Systematic Review Registration
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