Current status and influencing factors of laryngopharyngeal reflux disease in outpatients with laryngeal diseases: key considerations for clinical practice - Summary - MDSpire
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Current status and influencing factors of laryngopharyngeal reflux disease in outpatients with laryngeal diseases: key considerations for clinical practice
To explore the prevalence of laryngopharyngeal reflux disease (LPRD) in outpatients with laryngeal diseases, identify independent risk factors, and develop a practical prediction model for clinical application.
Key Findings:
1,650 outpatients were included in the study.
Independent risk factors for LPRD identified: age ≥65 years, BMI ≥ 25 kg/m2, smoking history, preference for strong tea, abnormal LES function, history of laryngeal surgery, and hypertension (all P < 0.001).
Abnormal LES function had the highest odds ratio (OR = 2.376, 95% CI: 1.985–2.836).
A weighted prediction model was developed with a total score ranging from 0 to 22 points.
The optimal diagnostic cutoff was 9.5 points, with sensitivity of 0.723 and specificity of 0.892.
The area under the curve (AUC) of the model was 0.891.
Interpretation:
LPRD is prevalent among outpatients with laryngeal diseases, influenced by multiple risk factors. The developed prediction model demonstrates good diagnostic performance, providing a reliable tool for early identification of high-risk patients.
Limitations:
The study is retrospective and may be subject to biases inherent in such designs.
Data was collected from a single tertiary hospital, which may limit generalizability.
Potential biases in retrospective studies may affect the reliability of the findings.
Conclusion:
The prediction model based on identified risk factors provides a reliable tool for early identification of high-risk patients with LPRD.
