To investigate the association between seasonal patterns and the occurrence of Ménière disease (MD).
Approach:
Data Sources: Search conducted in PubMed, Embase, Web of Science, the Cochrane Library, and major Chinese databases until July 2023.
Key Findings:
Five observational studies with 1,001,636 participants were included. Odds ratios for MD occurrence were 1.03 (95% CI 1.02–1.04) in spring, 0.92 (95% CI 0.91–0.93) in winter, and 1.04 (95% CI 0.85–1.26) in autumn, with summer as the reference. Subgroup and sensitivity analyses confirmed the robustness of the findings.
Interpretation:
The occurrence of MD may exhibit seasonal variation, with slightly higher occurrences in spring and lower in winter.
Limitations:
Limited number of included studies.
Geographic concentration in European and Asian populations.
Conclusion:
Further high-quality studies across diverse geographic regions are needed to provide more solid evidence regarding seasonal variations in MD.
