Non-histone lactylation in cancer: current advances and clinical implications
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By
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Yang, Robert Le
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Liang, Yiran
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May 18, 2026
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Objective:
To synthesize current advances in non-histone lactylation in cancer, emphasizing its regulatory mechanisms and functional impacts.
Key Findings:
- Non-histone lactylation modulates protein stability, enzymatic activity, and interactions.
- Lactylation plays a significant role in tumor biology, influencing proliferation and resistance to therapy.
Interpretation:
Non-histone lactylation represents a promising area for cancer research, linking metabolism and tumor biology.
Limitations:
Conclusion:
The review highlights the complexity and diversity of lactylation mechanisms and their implications in cancer.